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Benzodiazepines developed in the former Soviet Union (e.g. phenazepam, gidazepam etc.) Benzodiazepines predominantly used only in Japan (e.g. nimetazepam, flutoprazepam etc.) 4,5-cyclised benzodiazepines (e.g. ketazolam, cloxazolam etc.), and other compounds not researched by Roche.
The national drug code (NDC) is a unique product identifier used in the United States for drugs intended for human use. The Drug Listing Act of 1972 [ 1 ] [ 2 ] requires registered drug establishments to provide the Food and Drug Administration (FDA) with a current list of all drugs manufactured, prepared, propagated, compounded, or processed ...
Derivative test. In calculus, a derivative test uses the derivatives of a function to locate the critical points of a function and determine whether each point is a local maximum, a local minimum, or a saddle point. Derivative tests can also give information about the concavity of a function. The usefulness of derivatives to find extrema is ...
The fourth case studied here is ohmfentanyl. Ohmfentanyl has 3 potential stereocenters, which are best analogized by another piperidine derivative: N-(1-hydroxyethyl)-3-methyl-4-hydroxypiperidine. This uses a similar structure to analogize the three potential stereocenters in ohmfentanyl, namely the 4-C, the 3-C, and the β-C (beta carbon).
The material meets the definition of an explosive as prescribed in subpart C of this part, in which case it must be classed as an explosive (applies to acetone peroxide, for example) The material is forbidden from being offered for transportation according to 49CFR 172.101 of this subchapter or 49CFR 173.21;
Clascoterone, also known as cortexolone 17α-propionate or 11-deoxycortisol 17α-propionate, as well as 17α,21-dihydroxyprogesterone 17α-propionate or 17α,21-dihydroxypregn-4-en-3,20-dione 17α-propionate, is a synthetic pregnane steroid and a derivative of progesterone and 11-deoxycortisol (cortexolone). [17]
In re Caremark International Inc. Derivative Litigation, 698 A.2d 959 (Del. Ch. 1996), [1] is a civil action that came before the Delaware Court of Chancery. It is an important case in United States corporate law and discusses a director's duty of care in the oversight context.
Nicergoline is an ergot alkaloid derivative that acts as a potent and selective α 1A-adrenergic receptor antagonist. [7] The IC 50 of nicergoline in vitro has been reported to be 0.2 nM. [8] The primary action of nicergoline is to increase arterial blood flow by vasodilation. Furthermore, it is known that nicergoline inhibits platelet aggregation.