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PICO process. The PICO process (or framework) is a mnemonic used in evidence-based practice (and specifically evidence-based medicine) to frame and answer a clinical or health care related question, [1] though it is also argued that PICO "can be used universally for every scientific endeavour in any discipline with all study designs". [2]
HRDetect. HRDetect [1] (H omologous R ecombination D eficiency D etect) is a whole-genome sequencing (WGS)-based classifier designed to predict BRCA1 and BRCA2 deficiency based on six mutational signatures. Additionally, the classifier is able to identify similarities in mutational profiles of tumors to that of tumors with BRCA1 and BRCA2 ...
For example, the incidence of breast cancer in a woman in the United Kingdom at age 55 to 59 is estimated at 280 cases per 100.000 per year, [6] and the risk factor of having been exposed to high-dose ionizing radiation to the chest (for example, as treatments for other cancers) confers a relative risk of breast cancer between 2.1 and 4.0, [7 ...
Cost differences between the traditional methods and the triple test score varied based on the stages of breast mass evaluation. Traditional methods of evaluating breast masses include radiological assessments (e.g. mammography, ultrasound, MRI) and pathologic analyses (e.g. fine-needle aspiration cytology, core biopsy). [10]
The mainstay of breast cancer management is surgery for the local and regional tumor, followed (or preceded) by a combination of chemotherapy, radiotherapy, endocrine (hormone) therapy, and targeted therapy. Research is ongoing for the use of immunotherapy in breast cancer management. Management of breast cancer is undertaken by a ...
Breast cancer classification divides breast cancer into categories according to different schemes criteria and serving a different purpose. The major categories are the histopathological type, the grade of the tumor, the stage of the tumor, and the expression of proteins and genes. As knowledge of cancer cell biology develops these ...