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Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
The elimination half-life (t1/2) is the time required for the amount of drug in the body to decrease by half (eqn [5]). The half-life is independent of the dose of the drug administered and is a useful indicator of how fast a drug is removed from the body.
Terminal plasma half-life is the time required to divide the plasma concentration by two after reaching pseudo-equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half-life is a hybrid parameter controlled by plasma ….
Half-life in the context of medical science typically refers to the elimination half-life. The definition of elimination half-life is the length of time required for the concentration of a particular substance (typically a drug) to decrease to half of its starting dose in the body.
The elimination half-life is defined as the time required to reduce the plasma concentration to one half its value. The half-life is important in determining the time to reach steady-state drug concentrations, which for all practical purposes is within three to four half-lives.
Alternatively, terminal half-life (t1/2,z) is utilized as the single defining t1/2 for most drugs. However, accumulation at steady state may be markedly over predicted utilizing t1/2, z.
The elimination half-life (t 1/2) is the time required for the amount of drug in the body to decrease by half (Eq. 5). For drugs that exhibit linear PK, the half-life is independent of the dose of the drug administered and is a useful indicator of how fast a drug is removed from the body.
In pharmacokinetic (PK) analyses, the biological half-life T 1/2 is usually determined in the terminal phase after drug administration, which is readily calculated from the relationship T 1/2 = ln2/ λz where λz is the terminal-phase slope obtainable from non-compartmental analysis (NCA).
Terminal plasma half-life is the time required to divide the plasma concentration by two after reaching pseudo-equilibrium, and not the time required to eliminate half the administered dose.
Half-life in the context of medical science typically refers to the elimination half-life. The definition of elimination half-life is the length of time required for the concentration of a particular substance (typically a drug) to decrease to half of its starting dose in the body.