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Effective dose is a dose quantity in the International Commission on Radiological Protection (ICRP) system of radiological protection. [1]It is the tissue-weighted sum of the equivalent doses in all specified tissues and organs of the human body and represents the stochastic health risk to the whole body, which is the probability of cancer induction and genetic effects, of low levels of ...
The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...
The EC 50 of a quantal dose response curve represents the concentration of a compound where 50% of the population exhibit a response, [5] after a specified exposure duration. For clarification, a graded dose response curve shows the graded effect of the drug (y axis) over the dose of the drug (x axis) in one or an average of subjects.
"The calculation of the committed effective dose equivalent (CEDE) begins with the determination of the equivalent dose, H T, to a tissue or organ, T. Where D T ,R is the absorbed dose in rads (one gray, an SI unit, equals 100 rads) averaged over the tissue or organ, T, due to radiation type, R, and W R is the radiation weighting factor.
For such purposes, doses should be evaluated in terms of absorbed dose (in gray, Gy), and where high-LET radiations (e.g., neutrons or alpha particles) are involved, an absorbed dose, weighted with an appropriate RBE, should be used" Radiation weighting factors are largely based on the RBE of radiation for stochastic health risks. However, for ...
When a whole body is irradiated uniformly only the radiation weighting factor W R is used, and the effective dose equals the whole body equivalent dose. But if the irradiation of a body is partial or non-uniform the tissue factor W T is used to calculate dose to each organ or tissue. These are then summed to obtain the effective dose.
The Total effective dose equivalent (TEDE) is a radiation dosimetry quantity defined by the US Nuclear Regulatory Commission to monitor and control human exposure to ionizing radiation. It is defined differently in the NRC regulations and NRC glossary.
The internal radiation dose due to injection, ingestion or inhalation radioactive substances is known as committed dose.. The ICRP defines Committed effective dose, E(t) as the sum of the products of the committed organ or tissue equivalent doses and the appropriate tissue weighting factors W T, where t is the integration time in years following the intake.