Ads
related to: alpha 1 antitrypsin guidelines treatment options for osteoporosiswiserlifestyles.com has been visited by 100K+ users in the past month
Search results
Results From The WOW.Com Content Network
Alpha-1 antitrypsin or α 1-antitrypsin (A1AT, α 1 AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1 gene . A protease inhibitor , it is also known as alpha 1 –proteinase inhibitor ( A1PI ) or alpha 1 -antiproteinase ( A1AP ) because it inhibits various proteases (not just trypsin ). [ 5 ]
In medicine, protease inhibitor is often used interchangeably with alpha 1-antitrypsin (A1AT, which is abbreviated PI for this reason). [3] A1AT is indeed the protease inhibitor most often involved in disease, namely in alpha-1 antitrypsin deficiency.
Alpha-1 antitrypsin deficiency (A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. [1] Onset of lung problems is typically between 20 and 50 years of age. [ 1 ] This may result in shortness of breath , wheezing , or an increased risk of lung infections .
About Alpha-1 Antitrypsin (AAT) and AAT Deficiency Alpha-1 antitrypsin deficiency is an autosomal disorder that results in disease of the lungs and liver, and afflicts roughly 10,000 patients ...
Elastase is inhibited by the acute-phase protein α 1-antitrypsin (A1AT), which binds almost irreversibly to the active site of elastase and trypsin. A1AT is normally secreted by the liver cells into the serum. Alpha-1 antitrypsin deficiency (A1AD) leads to uninhibited destruction of elastic fibre by elastase; the main result is emphysema.
Protease inhibitory activity in blood plasma was first reported in the late 1800s, [13] but it was not until the 1950s that the serpins antithrombin and alpha 1-antitrypsin were isolated, [14] with the subsequent recognition of their close family homology in 1979.
John W. Walsh (February 4, 1949 – March 7, 2017) was an American non-profit leader and patient advocate.After being diagnosed with alpha-1 antitrypsin deficiency, he co-founded the Alpha-1 Foundation and AlphaNet, both of which serve people diagnosed with that condition, and the COPD Foundation, which serves people with chronic obstructive pulmonary disease.
15160 Ensembl ENSG00000099937 ENSMUSG00000022766 UniProt P05546 P49182 RefSeq (mRNA) NM_000185 NM_008223 NM_001331047 RefSeq (protein) NP_000176 NP_001317976 NP_032249 Location (UCSC) Chr 22: 20.77 – 20.79 Mb Chr 16: 17.15 – 17.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heparin cofactor II (HCII), a protein encoded by the SERPIND1 gene, is a coagulation factor that ...