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  2. Serotonin–norepinephrine–dopamine reuptake inhibitor

    en.wikipedia.org/wiki/Serotonin–norepinephrine...

    Cocaine is a relatively "balanced" inhibitor, although facilitation of dopaminergic neurotransmission is what has been linked to the reinforcing and addictive effects. In addition, cocaine has some serious limitations in terms of its cardiotoxicity [188] due to its local anesthetic activity. Thousands of cocaine users are admitted to emergency ...

  3. Monoamine transporter - Wikipedia

    en.wikipedia.org/wiki/Monoamine_transporter

    Monoamine transporters are established targets for many pharmacological agents that affect brain function, including the psychostimulants cocaine and amphetamine. Cocaine and amphetamine employ different mechanisms that both result in an increase in extracellular monoamines by decreasing reuptake.

  4. Cocaine dependence - Wikipedia

    en.wikipedia.org/wiki/Cocaine_dependence

    Cocaine is a powerful stimulant known to make users feel energetic, cheerful, talkative, etc. In time, negative side effects include increased body temperature, irregular or rapid heart rate, high blood pressure, increased risk of heart attacks, strokes and even sudden death from cardiac arrest.

  5. Cocaine - Wikipedia

    en.wikipedia.org/wiki/Cocaine

    The pharmacodynamics of cocaine involve the complex relationships of neurotransmitters (inhibiting monoamine uptake in rats with ratios of about: serotonin:dopamine = 2:3, serotonin:norepinephrine = 2:5). [110] [15] The most extensively studied effect of cocaine on the central nervous system is the blockade of the dopamine transporter protein.

  6. Epigenetics of cocaine addiction - Wikipedia

    en.wikipedia.org/wiki/Epigenetics_of_cocaine...

    This receptor had been seen to modulate the rewarding effects of cocaine, and receptor antagonists had blocked the acute locomotor stimulating effect and lowered behavioral sensitization. Changes in the sigma 1 receptor have been shown to modulate dopamine release, so shifts in its expression can change the behavioral responses to cocaine with ...

  7. Stimulant - Wikipedia

    en.wikipedia.org/wiki/Stimulant

    Stimulants can affect various functions, including arousal, attention, the reward system, learning, memory, and emotion. Effects range from mild stimulation to euphoria, depending on the specific drug, dose, route of administration, and inter-individual characteristics. Stimulants have a long history of use, both for medical and non-medical ...

  8. Mesolimbic pathway - Wikipedia

    en.wikipedia.org/wiki/Mesolimbic_pathway

    An addictive drug is defined as a substance that affects the mesolimbic system directly or indirectly by increasing extracellular levels of dopamine. [ 24 ] Common addictive substances such as cocaine , alcohol , and nicotine have been shown to increase extracellular levels of dopamine within the mesolimbic pathway, preferentially within the ...

  9. Psychopharmacology - Wikipedia

    en.wikipedia.org/wiki/Psychopharmacology

    The effects of cocaine are similar to those of amphetamines, though cocaine tends to have a shorter duration of effect. In high doses or with prolonged use, cocaine can result in a number of negative effects, including irritability, anxiety, exhaustion, total insomnia, and even psychotic symptomatology.