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  2. Nucleic acid sequence - Wikipedia

    en.wikipedia.org/wiki/Nucleic_acid_sequence

    A nucleic acid sequence is a succession of bases within the nucleotides forming alleles within a DNA (using GACT) or RNA (GACU) molecule. This succession is denoted by a series of a set of five different letters that indicate the order of the nucleotides. By convention, sequences are usually presented from the 5' end to the 3' end.

  3. Nucleotide base - Wikipedia

    en.wikipedia.org/wiki/Nucleotide_base

    The viral polymerase incorporates these compounds with non-canonical bases. These compounds are activated in the cells by being converted into nucleotides; they are administered as nucleosides as charged nucleotides cannot easily cross cell membranes. [citation needed] At least one set of new base pairs has been announced as of May 2014. [15]

  4. Nucleic acid structure - Wikipedia

    en.wikipedia.org/wiki/Nucleic_acid_structure

    Nucleic acids are formed when nucleotides come together through phosphodiester linkages between the 5' and 3' carbon atoms. [3] A nucleic acid sequence is the order of nucleotides within a DNA (GACT) or RNA (GACU) molecule that is determined by a series of letters. Sequences are presented from the 5' to 3' end and determine the covalent ...

  5. Nucleic acid notation - Wikipedia

    en.wikipedia.org/wiki/Nucleic_acid_notation

    The nucleic acid notation currently in use was first formalized by the International Union of Pure and Applied Chemistry (IUPAC) in 1970. [1] This universally accepted notation uses the Roman characters G, C, A, and T, to represent the four nucleotides commonly found in deoxyribonucleic acids (DNA).

  6. Non-canonical base pairing - Wikipedia

    en.wikipedia.org/wiki/Non-canonical_base_pairing

    One hydrogen bond from the Watson-Crick base pair is maintained (guanine O6 and cytosine N4) and the other occurs between guanine N7 and a protonated cytosine N3 (note that the Hoogsteen G-C base pair has two hydrogen bonds, while the Watson-Crick G-C base pair has three). [65] Figure 6: Four examples of wobble base pairs.

  7. Nucleic acid - Wikipedia

    en.wikipedia.org/wiki/Nucleic_acid

    One DNA or RNA molecule differs from another primarily in the sequence of nucleotides. Nucleotide sequences are of great importance in biology since they carry the ultimate instructions that encode all biological molecules, molecular assemblies, subcellular and cellular structures, organs, and organisms, and directly enable cognition, memory ...

  8. Single-nucleotide polymorphism - Wikipedia

    en.wikipedia.org/wiki/Single-nucleotide_polymorphism

    Although certain definitions require the substitution to be present in a sufficiently large fraction of the population (e.g. 1% or more), [1] many publications [2] [3] [4] do not apply such a frequency threshold. For example, a G nucleotide present at a specific location in a reference genome may be replaced by an A in a minority

  9. DNA - Wikipedia

    en.wikipedia.org/wiki/DNA

    In a nucleic acid double helix, the direction of the nucleotides in one strand is opposite to their direction in the other strand: the strands are antiparallel. The asymmetric ends of DNA strands are said to have a directionality of five prime end (5′ ), and three prime end (3′), with the 5′ end having a terminal phosphate group and the 3 ...