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General schema showing the relationships of the genome, transcriptome, proteome, and metabolome . A proteome is the entire set of proteins that is, or can be, expressed by a genome, cell, tissue, or organism at a certain time. It is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions.
It is thought that characterizing the proteome of blood plasma is a daunting challenge. The depth of the plasma proteome encompasses a dynamic range of more than 10 10 between the highest abundant protein (albumin) and the lowest (some cytokines) and is thought to be one of the main challenges for proteomics. [81]
The principal difference between structural genomics and traditional structural prediction is that structural genomics attempts to determine the structure of every protein encoded by the genome, rather than focusing on one particular protein. With full-genome sequences available, structure prediction can be done more quickly through a ...
The principal difference between structural genomics and traditional structural prediction is that structural genomics attempts to determine the structure of every protein encoded by the genome, rather than focusing on one particular protein. With full-genome sequences available, structure prediction can be done more quickly through a ...
176. Pharmacomics**: Study of drugs and their effects on the genome and proteome. 177. Polyomics**: Study of the complex interactions between multiple omes (genome, proteome, etc.). 178. Psychomics**: Study of the molecular basis of psychological traits and disorders. 179. Pulmonomics**: Study of the lungs and respiratory system at a molecular ...
For example, the genome contains the ORFeome, which gives rise to the transcriptome, which is translated to the proteome. Other terms are overlapping and refer to the structure and/or function of a subset of proteins (e.g. glycome, kinome). An omicist is a scientist who studies omeomics, cataloging all the “omics” subfields. [1]
Unlike the transcriptome, the translatome is a more accurate approximation for estimating the expression level of some genes, since the correlation between the proteome and translatome is higher than the correlation between the transcriptome and proteome. [5]
While there are significant differences among the genomes of human individuals (on the order of 0.1% due to single-nucleotide variants [9] and 0.6% when considering indels), [10] these are considerably smaller than the differences between humans and their closest living relatives, the bonobos and chimpanzees (~1.1% fixed single-nucleotide ...