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The coupling of chromatography with MS is a well developed chemical analysis strategy dating back from the 1950s. Gas chromatography (GC)–MS was originally introduced in 1952, when A. T. James and A. J. P. Martin were trying to develop tandem separation – mass analysis techniques. [9]
Orbitrap-based mass spectrometers are used in proteomics [13] [16] and are also used in life science mass spectrometry such as metabolism, metabolomics, [17] environmental, [18] food and safety analysis. [19]
A mass chromatogram is a representation of mass spectrometry data as a chromatogram, where the x-axis represents time and the y-axis represents signal intensity. [1] The source data contains mass information; however, it is not graphically represented in a mass chromatogram in favor of visualizing signal intensity versus time.
The first on-line coupling of gas chromatography to a mass spectrometer was reported in the late 1950s. [4] [5] An interest in coupling the methods had been suggested as early as December 1954, [6] but conventional recording techniques had too poor temporal resolution.
Software by Thermo Fisher Scientific used with mass spectrometry instruments. XCMS Online (Cloud-Based) Proprietary: Freely available and a widely used metabolomic and lipidomic data-processing platform.
Atmospheric pressure chemical ionization chamber cross section. Atmospheric pressure chemical ionization (APCI) is an ionization method used in mass spectrometry which utilizes gas-phase ion-molecule reactions at atmospheric pressure (10 5 Pa), [1] [2] commonly coupled with high-performance liquid chromatography (HPLC). [3]
The proposed method detailed a coupling device between liquid chromatographic columns and various methods of detection for gaseous samples; like mass spectrometry, electron capture, atomic adsorption, etc. Four different representations of the thermospray vaporizer were presented in the 1988 patent – UA4730111A.
Mass spectrometry is a scientific technique for measuring the mass-to-charge ratio of ions. It is often coupled to chromatographic techniques such as gas-or liquid chromatography and has found widespread adoption in the fields of analytical chemistry and biochemistry where it can be used to identify and characterize small molecules and proteins ().