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The biogenesis of the peroxisomal membrane and the insertion of peroxisomal membrane proteins (PMPs) requires the peroxins PEX19, PEX3, and PEX16. PEX19 is a PMP receptor and chaperone, which binds the PMPs and routes them to the peroxisomal membrane, where it interacts with PEX3, a peroxisomal integral membrane protein.
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and ...
72129 Ensembl ENSG00000162928 ENSMUSG00000020283 UniProt Q92968 Q9D0K1 RefSeq (mRNA) NM_002618 NM_023651 RefSeq (protein) NP_002609 NP_076140 Location (UCSC) Chr 2: 61.02 – 61.05 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene. It located on chromosome 2 next to KIAA1841 Interactions ...
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the cell. [1] [2] [note 1] Proteins can be targeted to the inner space of an organelle, different intracellular membranes, the plasma membrane, or to the exterior of the cell via secretion.
19298 Ensembl ENSG00000162735 ENSMUSG00000003464 UniProt P40855 Q8VCI5 RefSeq (mRNA) NM_001131039 NM_001193644 NM_002857 NM_001159525 NM_023041 NM_001356513 NM_001356514 RefSeq (protein) NP_001180573 NP_002848 NP_001152997 NP_075528 NP_001343442 NP_001343443 Location (UCSC) Chr 1: 160.28 – 160.29 Mb Chr 1: 171.95 – 171.96 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ...
Deficiencies are associated with several peroxisomal disorders. Peroxins serve several functions including the recognition of cytoplasmic proteins that contain peroxisomal targeting signals (PTS) that tag them for transport by peroxisomal proteins to the peroxisome.
18633 Ensembl ENSG00000121680 ENSMUSG00000027222 UniProt Q9Y5Y5 Q91XC9 RefSeq (mRNA) NM_004813 NM_057174 NM_145122 RefSeq (protein) NP_004804 NP_476515 NP_660104 Location (UCSC) Chr 11: 45.91 – 45.92 Mb Chr 2: 92.21 – 92.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene. Function The ...
Microbody structure - a peroxisome. Microbodies are different type of bodies present in the cytosol, also known as cytosomes. A microbody is usually a vesicle with a spherical shape, ranging from 0.2-1.5 micrometers in diameter. [1]