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Age-related decrease in gray matter volume was the largest contribution to changes in brain volume. Moreover, neuronal density appears to decrease, white matter microstructure gets altered and energy metabolism in the cerebellum gets altered. [16] General cortical atrophy occurs in aging and e.g. the caudate nucleus volume appears to decrease.
In aging, degradation of white matter structure has emerged as an important general factor, further focusing attention on the critical white matter connections. [citation needed] Exercise affects many people young and old. [14] For the young, if exercise is introduced it can form a constructive habit that can be instilled throughout adulthood.
For example, deep white matter hyperintensities are 2.5 to 3 times more likely to occur in bipolar disorder and major depressive disorder than control subjects. [ 3 ] [ 4 ] WMH volume, calculated as a potential diagnostic measure, has been shown to correlate to certain cognitive factors. [ 5 ]
Also known as “sundowner’s syndrome,” sundowning is a set of symptoms or behaviors that can be seen in some people with Alzheimer’s disease and dementia, according to the Alzheimer’s ...
The first symptoms are often mistakenly attributed to aging or stress. [34] Detailed neuropsychological testing can reveal mild cognitive difficulties up to eight years before a person fulfills the clinical criteria for diagnosis of Alzheimer's disease. [35] These early symptoms can affect the most complex activities of daily living. [36]
Researchers analyzing the white matter of superagers over a 5-year period found that despite comparable overall white matter health with typical older adults, superagers exhibited superior ...
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