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Scientist Otto Warburg, whose research activities led to the formulation of the Warburg hypothesis for explaining the root cause of cancer.. The Warburg hypothesis (/ ˈ v ɑːr b ʊər ɡ /), sometimes known as the Warburg theory of cancer, postulates that the driver of carcinogenesis (cancer formation) is insufficient cellular respiration caused by insult (damage) to mitochondria. [1]
Otto Warburg postulated this change in metabolism is the fundamental cause of cancer, [8] a claim now known as the Warburg hypothesis. Today, mutations in oncogenes and tumor suppressor genes are thought to be responsible for malignant transformation , and the Warburg effect is considered to be a result of these mutations rather than a cause.
Otto Heinrich Warburg (German pronunciation: [ˈɔto ˈvaːɐ̯bʊʁk] ⓘ, / ˈ v ɑːr b ɜːr ɡ /; 8 October 1883 – 1 August 1970) was a German physiologist, medical doctor, and Nobel laureate. He served as an officer in the elite Uhlan (cavalry regiment) during the First World War, and was awarded the Iron Cross (1st Class) for bravery ...
In the absence of hypoxic conditions (i.e. physiological levels of oxygen), cancer cells preferentially convert glucose to lactate, according to Otto H. Warburg, who believed that aerobic glycolysis was the key metabolic change in cancer cell malignancy. The "Warburg effect" was later coined to describe this metabolic shift. [6]
The Warburg effect, named for Otto Heinrich Warburg, may refer to: Warburg effect (embryology) Warburg effect inversion; Warburg effect (oncology)
This phenomenon was first described in 1930 by Otto Warburg and is referred to as the Warburg effect. The Warburg hypothesis claims that cancer is primarily caused by dysfunctionality in mitochondrial metabolism, rather than because of the uncontrolled growth of cells. A number of theories have been advanced to explain the Warburg effect.
The unannounced trip to Merseyside was William and Kate’s first joint official outing since the princess’s course of chemotherapy cancer treatment ended in the summer. 9 November, Saturday
A few months later, Bloodgood asked Geschickter to come back and help him at the new Garvan Cancer Research Laboratory. Geschickter agreed, and before starting work made a tour of pathology laboratories in Europe, including the biochemistry unit run by Otto Heinrich Warburg in Berlin. His main interest after this was in cancer research and ...