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Acute megakaryoblastic leukemia (AMKL) is life-threatening leukemia in which malignant megakaryoblasts proliferate abnormally and injure various tissues. Megakaryoblasts are the most immature precursor cells in a platelet-forming lineage; they mature to promegakaryocytes and, ultimately, megakaryocytes which cells shed membrane-enclosed particles, i.e. platelets, into the circulation.
Increased amounts of megakaryoblasts in the bone marrow may indicate a disease state. [4] An example of this is acute megakaryoblastic leukemia, which occurs when the level of megakaryoblasts in the bone marrow exceeds 20%. [5]
Acute megakaryoblastic leukemia: A life-threatening leukemia in which malignant megakaryoblasts proliferate abnormally and injure various tissues. Blastic plasmacytoid dendritic cell neoplasm : A rare hematologic malignancy which is a malignancy of plasmacytoid dendritic cells .
Some types may develop into acute myeloid leukemia. [ 3 ] Risk factors include previous chemotherapy or radiation therapy , exposure to certain chemicals such as tobacco smoke , pesticides , and benzene , and exposure to heavy metals such as mercury or lead . [ 3 ]
For example, people with Down syndrome have a significantly increased risk of developing forms of acute leukemia (especially acute myeloid leukemia), and Fanconi anemia is a risk factor for developing acute myeloid leukemia. [46] Mutation in SPRED1 gene has been associated with a predisposition to childhood leukemia. [54]
Example of platelets release in mature megakaryocytes. This footage shows the formation and spontaneous release of platelets (small round-shaped blood cells), imaged with a live-cell imaging microscope. Thrombopoietin (TPO) is a 353-amino acid protein encoded on chromosome 3p27.
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. [1]
Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original diagnosis of leukemia. In most cases, these can be classified according to the lineage, myeloid or lymphoid , of the malignant cells that grow uncontrolled, but some are mixed and for those such an assignment is not possible.