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A Michael reaction is used as a mechanistic step by many covalent inhibitor drugs. Cancer drugs such as ibrutinib, osimertinib, and rociletinib have an acrylamide functional group as a Michael acceptor. The Michael donor on the drug reacts with a Michael acceptor in the active site of an enzyme. This is a viable cancer treatment because the ...
When a musical key or key signature is referred to in a language other than English, that language may use the usual notation used in English (namely the letters A to G, along with translations of the words sharp, flat, major and minor in that language): languages which use the English system include Irish, Welsh, Hindi, Japanese (based on katakana in iroha order), Korean (based on hangul in ...
Each year, live concerts and online events have been held. There are also SoundCloud and Spotify playlists available from each year. [citation needed] On Piano Day 2018, Christian Henson of Spitfire Audio launched a website and YouTube channel called Pianobook, dedicated to creating and sharing sampled instruments for free.
This is a list of the fundamental frequencies in hertz (cycles per second) of the keys of a modern 88-key standard or 108-key extended piano in twelve-tone equal temperament, with the 49th key, the fifth A (called A 4), tuned to 440 Hz (referred to as A440). [1] [2] Every octave is made of twelve steps called semitones.
Performance Today was created by National Public Radio (NPR), and went on the air in 1987. The program was founded by NPR vice president for cultural programming Dean Boal, who gave Performance Today its name, and who, along with NPR colleagues Doug Bennet, Jane Couch, Ellen Boal, and retired Baldwin Piano Company president Lucien Wulsin, secured the series' initial funding.
Keegan-Michael Key and Elle Key are as much producing partners as they are husband and wife. Those two roles are “very much interwoven,” Keegan-Michael, 53, tells PEOPLE in this week’s issue.
Keegan-Michael Key and his wife, Elle Key, have been going strong since 2017. Following his split from ex-wife Cynthia Blaise in 2015, Keegan-Michael moved on with Elle in January 2017. The duo ...
YouTube (formerly YouTube Spotlight) is the official YouTube channel for the American video-sharing platform YouTube, spotlighting videos and events on the platform. Events shown on the channel include YouTube Comedy Week and the YouTube Music Awards .