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If left untreated, a typical major depressive episode may last for several months. [32] About 20% of these episodes can last two years or more, while about half end spontaneously. However, even after the major depressive episode is over 20% to 30% of patients have residual symptoms, which can be distressing and associated with disability. [5]
The diagnosis hinges on the presence of single or recurrent major depressive episodes. [117] Further qualifiers are used to classify both the episode itself and the course of the disorder. The category Unspecified Depressive Disorder is diagnosed if the depressive episode's manifestation does not meet the criteria for a major depressive episode ...
A 2003 study proposed that a gene-environment interaction (GxE) may explain why life stress is a predictor for depressive episodes in some individuals, but not in others, depending on an allelic variation of the serotonin-transporter-linked promoter region . [15]
Bipolar disorder can also involve depressive episodes, which have the same symptoms that people with major depressive disorder experience. Symptoms of a depressive episode can include : Feeling ...
Mood swings in bipolar I: Episodic, [42] manic episodes (severe degree) occur continuously for 7 days, [30] depressive episodes for weeks, [45] [46] and sometimes erratic episodes at moderate degree in between episodes. [30] Alterations in bipolar I and II can be rapid cyclic, which means changes of mood happen 4 times or more within a year. [47]
Psychotic major depression (PMD), or simply psychotic depression, is the term for a major depressive episode, in particular of melancholic nature, wherein the patient experiences psychotic symptoms such as delusions or, less commonly, hallucinations. These are most commonly mood-congruent (content coincident with depressive themes).