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In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat. [1] Lipogenesis encompasses both fatty acid and triglyceride synthesis , with the latter being the process by which fatty acids are esterified to glycerol before ...
In animals, these fats are obtained from food and are synthesized by the liver. [1] Lipogenesis is the process of synthesizing these fats. [2] [3] The majority of lipids found in the human body from ingesting food are triglycerides and cholesterol. [4] Other types of lipids found in the body are fatty acids and membrane lipids.
The 100 g (0.2 lb) or so of glycogen stored in the liver is depleted within one day of starvation. [11] Thereafter the glucose that is released into the blood by the liver for general use by the body tissues, has to be synthesized from the glucogenic amino acids and a few other gluconeogenic substrates, which do not include fatty acids. [12]
The liver is a major metabolic organ exclusively found in vertebrate ... lipogenesis, and the production ... (Job 19:9, etc.) and under that definition appears many ...
Second, insulin promotes the production of new FFAs in the liver via de novo lipogenesis; this production of liver fats continues to be stimulated by insulin, even when other tissues are insulin-resistant. [20] These FFAs are combined back into triglycerides in the liver, forming the major constituent of the accumulated fat in the liver. [20]
Lipogenesis [ edit ] While lipolysis is triglyceride hydrolysis (the process by which triglycerides are broken down), esterification is the process by which triglycerides are formed.
Normally, de novo lipogenesis occurs primarily in adipose tissue. But in conditions of obesity , insulin resistance , or type 2 diabetes de novo lipogenesis is reduced in adipose tissue (where carbohydrate-responsive element-binding protein (ChREBP) is the major transcription factor ) and is increased in the liver (where sterol regulatory ...
Lipogenesis plays a role in energy intake and expenditure, lipid deposition, insulin sensitivity, cancer, cardiovascular disease, the immune system, and neurogenesis. Potential therapeutic applications for inhibitors include non-alcoholic fatty liver disease, type 2 diabetes, and cardiovascular disease. [1] [2]