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Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. [1] Serious side effects include problems with vision, muscle damage, seizures , and low blood cell levels . [ 1 ] [ 4 ] Chloroquine is a member of the drug class 4-aminoquinoline . [ 1 ]
Quinine, like chloroquine, inactivates enzymes in the lysosomes of cells and has an anti-inflammatory effect, hence its use in the treatment of rheumatoid arthritis. However, inactivation of these enzymes can also cause abnormal accumulation of glycogen and phospholipids in lysosomes, causing toxic myopathy. It is possible this action is the ...
This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available. [5] [6] While sometimes used for nocturnal leg cramps, quinine is not recommended for this purpose due to the risk of serious side effects. [5] It can be taken by mouth or intravenously. [5]
The disease is named because it is a porphyria that often presents with skin manifestations later in life. The disorder results from low levels of the enzyme responsible for the fifth step in heme production. Heme is a vital molecule for all of the body's organs. It is a component of hemoglobin, the molecule that carries oxygen in the blood.
Quinidine-induced thrombocytopenia (low platelet count) is mediated by the immune system, and may lead to thrombocytic purpura. Quinidine intoxication can lead to a collection of symptoms collectively known as cinchonism, with tinnitus (ringing in the ears) being among the most characteristic and common symptoms of this toxicity syndrome.
Among the quinoline alkaloids are the cinchona alkaloids quinine and quinidine, which are important due to their therapeutic potential, furthermore cinchonine and cinchonidine, as well as some furoquinoline alkaloids and acridine alkaloids.
Unfortunately, leishmaniasis is an orphan disease in developed nations, and almost all the current treatment options are toxic with significant side effects. [18] The best-studied treatments for ACML caused by two Leishmania species are listed below. However, one should note that most of the studies examining treatments of ACML were poorly ...
Common side effects may include vomiting, headache, blurred vision, and muscle weakness. [3] Severe side effects may include allergic reactions, retinopathy, and irregular heart rate. [3] [4] Although all risk cannot be excluded, it remains a treatment for rheumatic disease during pregnancy. [5]