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Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. [1] Serious side effects include problems with vision, muscle damage, seizures, and low blood cell levels. [1] [4] Chloroquine is a member of the drug class 4-aminoquinoline. [1]
Quinine, like chloroquine, inactivates enzymes in the lysosomes of cells and has an anti-inflammatory effect, hence its use in the treatment of rheumatoid arthritis. However, inactivation of these enzymes can also cause abnormal accumulation of glycogen and phospholipids in lysosomes, causing toxic myopathy. It is possible this action is the ...
Quinine (and quinidine) ... urticaria, serious skin rashes, ... other drugs that have fewer side effects, such as chloroquine, ...
Tonic water is known to cause fixed eruptions, which is a type of skin reaction to drugs, [15] due to the quinine content. Various scientific journals have reported that repeated intake of tonic water can cause fixed eruptions with varying severity, with one reporting the onset of Stevens-Johnson syndrome . [ 16 ]
Among the quinoline alkaloids are the cinchona alkaloids quinine and quinidine, which are important due to their therapeutic potential, furthermore cinchonine and cinchonidine, as well as some furoquinoline alkaloids and acridine alkaloids.
Quinidine's effect on I Na is known as a 'use dependent block'. This means at higher heart rates, the block increases, while at lower heart rates, the block decreases. The effect of blocking the fast inward sodium current causes the phase 0 depolarization of the cardiac action potential to decrease (decreased V max).
A man who ate the carnivore diet had cholesterol of 1,000 and developed yellow lumps on his hands, deposits of excess cholesterol under his skin. Man on carnivore diet has cholesterol of 1,000 ...
Drug-induced urticaria occurs by immunologic and nonimmunologic mechanisms. [3] The primary mechanism for drug-induced urticaria involves a type-I hypersensitivity reaction mediated by IgE antibodies, commonly observed with ß-lactam use.