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The X chromosome is one of the two sex chromosomes in many organisms, including mammals, and is found in both males and females. It is a part of the XY sex-determination system and XO sex-determination system.
X-linked recessive inheritance. X-linked recessive inheritance is a mode of inheritance in which a mutation in a gene on the X chromosome causes the phenotype to be always expressed in males (who are necessarily hemizygous for the gene mutation because they have one X and one Y chromosome) and in females who are homozygous for the gene mutation (see zygosity).
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In the XY sex-determination system, the female-provided ovum contributes an X chromosome and the male-provided sperm contributes either an X chromosome or a Y chromosome, resulting in female (XX) or male (XY) offspring, respectively. Hormone levels in the male parent affect the sex ratio of sperm in humans. [25]
In the absence of a Y chromosome, the fetus will undergo female development. This is because of the presence of the sex-determining region of the Y chromosome, also known as the SRY gene. [5] Thus, male mammals typically have an X and a Y chromosome (XY), while female mammals typically have two X chromosomes (XX).
Most spiders have a variation of the XO system in which males have two different X chromosomes (X 1 X 2 O), while females have a pair of X 1 chromosomes and a pair of X 2 chromosomes (X 1 X 1 X 2 X 2). [1] Some spiders have more complex systems involving as many as 13 different X chromosomes. [1] Some Drosophila species have XO males. [10]
The X-chromosome has a special path of inheritance patterns and can be useful in significantly narrowing down possible ancestor lines compared to autosomal DNA. For example, an X-chromosome match with a male can only have come from his maternal side. [17] Like autosomal DNA, X-chromosome DNA undergoes random recombination at each generation ...
The centre also appears to be important in chromosome counting: ensuring that random inactivation only takes place when two or more X-chromosomes are present. The provision of an extra artificial Xic in early embryogenesis can induce inactivation of the single X found in male cells. [6] The roles of Xist and Tsix appear to be antagonistic.