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Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. [5] [6] Telomerases are part of a distinct subgroup of RNA-dependent polymerases.
Telomerase is a reverse transcriptase enzyme that carries its own RNA molecule (e.g., with the sequence 3′-CCCAAUCCC-5′ in Trypanosoma brucei) [3] which is used as a template when it elongates telomeres. Telomerase is active in gametes and most cancer cells, but is normally absent in most somatic cells.
The catalytic subunit of telomerase called human telomerase reverse transcriptase , represents a potential universal target for cancer immunotherapy. [citation needed] Gaudernack was the first to develop therapeutic cancer vaccines based on immunogenic peptides derived from hTERT.
Telomerase RNA component, also known as TR, TER or TERC, is an ncRNA found in eukaryotes that is a component of telomerase, the enzyme used to extend telomeres. [ 3 ] [ 4 ] TERC serves as a template for telomere replication ( reverse transcription ) by telomerase.
With this product, the c-Myc protein functions in the processes of apoptosis and cell growth or development and as a transcriptional control on human telomerase reverse transcriptase. [67] Interaction of c-Myc promoter G-quadruplex with NM23H2 was shown to regulate c-Myc in cancer cells in 2009 [ 42 ]
The Myc family consists of three related human genes: c-myc , l-myc , and n-myc . c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc. In cancer, c-myc is often constitutively (persistently) expressed.
He studies telomerase, the enzyme that copies the telomeric sequences and lengthens them. [8] The active site protein subunits of telomerase comprise a new class of reverse transcriptases, enzymes previously thought to be restricted to viruses and transposable elements. Telomerase is activated in 90% of human
72400 Ensembl ENSG00000254093 ENSMUSG00000021958 UniProt Q96BK5 Q9CZX5 RefSeq (mRNA) NM_017884 NM_001284356 NM_028228 RefSeq (protein) NP_001271285 NP_060354 NP_082504 Location (UCSC) n/a Chr 14: 64.1 – 64.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse PIN2/TERF1 -interacting telomerase inhibitor 1, also known as PINX1, is a human gene. PINX1 is also known as PIN2 interacting ...