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Rhinitis medicamentosa (or RM, also known as rebound congestion) is a condition of rebound nasal congestion suspected to be brought on by extended use of topical decongestants (e.g., oxymetazoline, phenylephrine, xylometazoline, and naphazoline nasal sprays) and certain oral medications (e.g., sympathomimetic amines and various 2-imidazolines) that constrict blood vessels in the lining of the ...
Extended usage of xylometazoline can result in decreased effectiveness or a buildup of tolerance against the drug. [12] The number of receptors decreases, and when the administration of the drug is ceased, chronic congestion can occur; this is called rhinitis medicamentosa , commonly referred to as rebound congestion.
Oxymetazoline, sold under the brand name Afrin among others, is a topical decongestant and vasoconstrictor medication. It is available over-the-counter as a nasal spray to treat nasal congestion and nosebleeds, as eye drops to treat eye redness due to minor irritation, and (in the United States) as a prescription topical cream to treat persistent facial redness due to rosacea in adults.
Phenylephrine, sold under the brand names Neosynephrine and Sudafed PE among others, is a medication used as a decongestant for uncomplicated nasal congestion in the form of a nasal spray or oral tablet, [5] to dilate the pupil, to increase blood pressure given intravenously in cases of low blood pressure, and to relieve hemorrhoids as a suppository.
"I was actually really addicted to nose spray like Afrin, before. Like for years. Like at award shows I would have to pick out the right clutch to be able to fit my Afrin in it.
Potentially serious side effects are unusual, but include severe allergic reaction, eye pain or change in vision, or urinary retention. It is considered safe during pregnancy, but it can pass into breast milk and may harm a nursing baby. [11] Ipratropium bromide was patented in 1966, and approved for medical use in 1974. [12]
Studies on Rabbits. Similar problems were reported in pregnant rabbits given Ozempic.. Researchers gave rabbits 0.0010mg, 0.0025mg, or 0.0075mg of semaglutide per kilogram of body weight per day.
Later, Davis also had a hysterectomy during an operation on an abscessed fallopian tube, telling the doctor, "if I wake up and my uterus is still here, I'm going to kick your ass," she recalled.