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The basic unit of the Reactome database is a reaction; reactions are then grouped into causal chains to form pathways [115] The Reactome data model allows us to represent many diverse processes in the human system, including the pathways of intermediary metabolism, regulatory pathways, and signal transduction, and high-level processes, such as ...
High protein expression of RANKL is commonly detected in the lungs, thymus and lymph nodes. Low protein expression is found in bone marrow , the stomach , peripheral blood , the spleen , the placenta , leukocytes , the heart , the thyroid , and skeletal muscle . [ 9 ]
RANK is the receptor for RANK-Ligand and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It is associated with bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development.
TAAR1 is a high-affinity receptor for amphetamine, methamphetamine, dopamine, and trace amines which mediates some of their cellular effects in monoamine neurons within the central nervous system. [ 7 ] [ 10 ] The primary known endogenous ligands of the human TAAR1 (hTAAR1) receptor, by rank order of potency, are: tyramine > β-phenethylamine ...
13857 Ensembl ENSG00000187266 ENSMUSG00000006235 UniProt P19235 P14753 RefSeq (mRNA) NM_000121 NM_010149 RefSeq (protein) NP_000112 NP_034279 Location (UCSC) Chr 19: 11.38 – 11.38 Mb Chr 9: 21.87 – 21.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52 kDa peptide with a single ...
cAMP represented in three ways Adenosine triphosphate. Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within cells, that is important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms ...
It causes them to break apart from the catalytic sub-units. The catalytic sub-units make their way in to the nucleus to influence transcription. Further effects mainly depend on cAMP-dependent protein kinase, which vary based on the type of cell. cAMP-dependent pathway is necessary for many living organisms and life processes.
High levels of Interleukin 8 have been shown to reduce the likelihood of positive responses to antipsychotic medication in schizophrenia. [24] IL-8 has also been implicated in the pathology of cystic fibrosis. Through its action as a signalling molecule IL-8 is capable of recruiting and guiding neutrophils to the lung epithelium.