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Finasteride is also used to treat male pattern baldness (androgenic alopecia) in men, a condition that develops in up to 80% of Caucasian men aged 70 and over. [ 24 ] [ 4 ] In the United States, finasteride and minoxidil are the only two FDA approved drugs for the treatment of male pattern hair loss as of 2017. [ 25 ]
A clinical study that compared the effects of oral finasteride against a finasteride 0.25% topical solution was carried out on 24 men with androgenetic alopecia.
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In comparison, the rate of improvement was 80.5 percent for men who used finasteride and just 59 percent for men who only used minoxidil. You may have heard of topical minoxidil under the brand ...
[40] 5α-DHP is a major hormone in circulation of normal cycling and pregnant women. [ 41 ] Other enzymes compensate to a degree for the absent conversion of 5α-reductase, specifically with local expression at the skin of reductive 17β-hydroxysteroid dehydrogenase , and oxidative 3α-hydroxysteroid dehydrogenase and 3β-hydroxysteroid ...
Other 5α-reductase inhibitors such as finasteride (a type 2 inhibitor) have been used off-label to treat excessive hair growth in women with hirsutism. [ 3 ] [ 23 ] Since dutasteride is an inhibitor of both type 1 and 2 5α-reductases, it could theoretically be a more effective therapy for hirsutism.