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Ultrasound imaging deposits energy over a large area while therapeutic ultrasound focuses the energy on one target site. Focused ultrasound for intracrainial drug delivery is a non-invasive technique that uses high-frequency sound waves (focused ultrasound, or FUS) to disrupt tight junctions in the blood–brain barrier (BBB), allowing for increased passage of therapeutics into the brain.
High-intensity focused ultrasound (HIFU), ... One of the first applications of HIFU was the treatment of Parkinson's disease in the 1940s. Although ineffective at the ...
This is counteracted by a focused ultrasound. The ultrasound increases the permeability of the blood–brain barrier by causing interference in the tight junctions in localized areas. This combined with the microbubbles allows for a very specific area of diffusion for the microbubbles , because they can only diffuse where the ultrasound is ...
Thalamotomy can be performed without incisions using ultrasound waves. The ultrasound waves are focused to the thalamus, thus cause thalamotomy through an intact skull. This procedure uses MRI guidance to localize the thalamus. The ultrasound waves cause gradual warming of the tissue until ablation occurs, seen clinically as resolution of tremor.
Ali R. Rezai (born 1965) [1] is an Iranian-born American neurosurgeon and neuroscientist. [2] [3] His work and research has focused on neuromodulation treatments for patients with neurological and mental health conditions, [4] including neuromodulation techniques such as deep brain stimulation (DBS) through brain chip implants to treat Parkinson's disease tremors, obsessive–compulsive ...
However, the energy applied from ultrasound can result in tissue damage. Fortunately, studies have demonstrated that this risk can be reduced if preformed microbubbles are first injected before focused ultrasound is applied, reducing the energy required from the ultrasound. [26] This technique has applications in the treatment of various diseases.
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