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The African clawed frog or platanna, Xenopus laevis, was first widely used in laboratories in pregnancy assays in the first half of the 20th century.When human chorionic gonadotropin, a hormone found in substantial quantities in the urine of pregnant women, is injected into a female X. laevis, it induces them to lay eggs.
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Prior to dissection for educational purposes, chloroform was administered to this common sand frog to induce anesthesia and death. The extent to which animal testing causes pain and suffering, and the capacity of animals to experience and comprehend them, is the subject of much debate. [166] [167]
The Hogben test procedure consisted of injecting a sample of women's urine into the skin on the back of the frog, specifically into the dorsal lymph sac. [16] Around 12 hours later, results could be seen. If the woman was pregnant, then the frog would be ovulating, and a small cluster of eggs could be seen at the rear end of the frog.
One of Pavlov’s dogs with a saliva-catch container and tube surgically implanted in its muzzle, Pavlov Museum, 2005. The history of animal testing goes back to the writings of the Ancient Greeks in the 4th and 3rd centuries BCE, with Aristotle (384–322 BCE) and Erasistratus (304–258 BCE) one of the first documented to perform experiments on nonhuman animals. [1]
A key principle in the dissection of human cadavers (sometimes called androtomy) is the prevention of human disease to the dissector.Prevention of transmission includes the wearing of protective gear, ensuring the environment is clean, dissection technique [2] and pre-dissection tests to specimens for the presence of HIV and hepatitis viruses. [3]
A later alternative to the rabbit test, known as the "Hogben test", used the African clawed frog, and yielded results without the need to cut the animal open. [6] Modern pregnancy tests continue to operate on the basis of testing for the presence of the hormone hCG in the blood or urine, but they no longer require the use of a live animal.
Download QR code; In other projects Appearance. move to sidebar hide ... English: Frog dissection during practical work at Faculty of Biology, Moscow State University.