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A symporter is an integral membrane protein that is involved in the transport of two (or more) different molecules across the cell membrane in the same direction. The symporter works in the plasma membrane and molecules are transported across the cell membrane at the same time, and is, therefore, a type of cotransporter .
The antiporter can now bind to its second substrate and transport it in the opposite direction by taking on its transient substrate-bound open state. This is followed by an occluded, substrate-bound state that is still facing the cytosol, a conformation change with a temporary fully-occluded intermediate stage, and a return to the antiporter's ...
Na-K-2Cl symporter – This specific cotransporter regulates the cell volume by controlling the water and electrolyte content within the cell. [15] The Na-K-2Cl Cotransporter is vital in salt secretion in secretory epithelia cells along with renal salt reabsorption. [16] Two variations of the Na-K-2Cl symporter exist and are known as NKCC1 and ...
Antiporter proteins transport one molecule down its concentration gradient to transport another molecule against its concentration gradient, but the molecules diffuse in opposite directions. As symporters and antiporters are involved in coupling the transport of two molecules, they are commonly referred to as cotransporters .
The SGLT1 protein is a symporter system because it passes both glucose and sodium in the same direction, from the lumen of the intestine to inside the intestinal cells. [ 4 ] An example of an antiporter mediated transport protein is the sodium-calcium antiporter, a transport protein involved in keeping the cytoplasmic concentration of calcium ...
An example is the glucose symporter SGLT1, which co-transports one glucose (or galactose) molecule into the cell for every two sodium ions it imports into the cell. [27] This symporter is located in the small intestines, [28] heart, [29] and brain. [30] It is also located in the S3 segment of the proximal tubule in each nephron in the kidneys. [31]
The glucose transporter (GLUTs) is a type of uniporter responsible for the facilitated diffusion of glucose molecules across cell membranes. [9] Glucose is a vital energy source for most living cells, however, due to its large size, it cannot freely move through the cell membrane. [16]
The sodium-calcium exchanger (often denoted Na + /Ca 2+ exchanger, exchange protein, or NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na +) by allowing Na + to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca 2+).