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In plants, sucrose transport is distributed throughout the plant by the proton-pump where the pump creates a gradient of protons so that there are many more on one side of the membrane than the other. As the protons diffuse back across the membrane, the free energy liberated by this diffusion is used to co-transport sucrose. In mammals, glucose ...
The transport of glucose across the proximal tubule cell membrane involves a complex process of secondary active transport (also known as co-transport). [3] This process begins with the Na + /K + ATPase on the basolateral membrane. This enzyme uses ATP to pump 3 sodium ions out of the cell into the blood while bringing 2 potassium ions into the ...
Sodium/glucose cotransporter 1 (SGLT1) also known as solute carrier family 5 member 1 is a protein in humans that is encoded by the SLC5A1 gene [4] [5] which encodes the production of the SGLT1 protein to line the absorptive cells in the small intestine and the epithelial cells of the kidney tubules of the nephron for the purpose of glucose uptake into cells. [6]
There are several known sodium-dependent phosphate transporters found in humans. For example, the protein 2A is encoded by the solute carrier family 34, member 1 (SLC34A1) gene [7] and facilitates uptake of phosphate for normal cellular functions including cellular metabolism, signal transduction, and nucleic acid and lipid synthesis.
Crane's discovery of cotransport was the first ever proposal of flux coupling in biology. [16] Crane in 1961 was the first to formulate the cotransport concept to explain active transport. Specifically, he proposed that the accumulation of glucose in the intestinal epithelium across the brush border membrane was [is] coupled to downhill Na+ ...
In cellular biology, membrane transport refers to the collection of mechanisms that regulate the passage of solutes such as ions and small molecules through biological membranes, which are lipid bilayers that contain proteins embedded in them. The regulation of passage through the membrane is due to selective membrane permeability – a ...
An example of an antiporter mediated transport protein is the sodium-calcium antiporter, a transport protein involved in keeping the cytoplasmic concentration of calcium ions in the cells, low. This transport protein is an antiporter system because it transports three sodium ions across the plasma membrane in exchange for a calcium ion, which ...
A symporter is an integral membrane protein that is involved in the transport of two (or more) different molecules across the cell membrane in the same direction. The symporter works in the plasma membrane and molecules are transported across the cell membrane at the same time, and is, therefore, a type of cotransporter .