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20666 Ensembl ENSG00000176887 ENSMUSG00000063632 UniProt P35716 Q7M6Y2 RefSeq (mRNA) NM_003108 NM_009234 RefSeq (protein) NP_003099 NP_033260 Location (UCSC) Chr 2: 5.69 – 5.7 Mb Chr 12: 27.38 – 27.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene. Function This intronless gene encodes a member ...
MOPP is a combination chemotherapy regimen used to treat Hodgkin lymphoma. The acronym is derived from the component drugs of the regimen: ustargen (also known as mechlorethamine, chlormethine, mustine, nitrogen mustard, or MSD) ncovin (also known as Vincristine or VCR) rocarbazine (also known as Matulane or Natulan)
R-HDAC, or R-HD-AraC (ituximab plus (H)igh (D)ose ra-) is a chemotherapy regimen that is used, alternating with R-Maxi-CHOP, as part of so-called "Nordic protocol" of treating mantle cell lymphoma. It consists of monoclonal antibody rituximab and high-dose antimetabolite cytarabine .
As of 2007, ABVD is widely used as the initial chemotherapy treatment for newly diagnosed Hodgkin lymphoma. [citation needed] It has been the most effective and least toxic chemotherapy regimen available for treating early-stage Hodgkin Lymphoma. [1]
This regimen can also be combined with the monoclonal antibody rituximab if the lymphoma is of B cell origin; this combination is called R-CHOP. In 2002, a randomized controlled trial showed a higher complete response rate for R-CHOP vs CHOP in elderly patients with Diffuse Large-B-Cell Lymphoma (76% vs 63%). [ 4 ]
Loncastuximab tesirine, sold under the brand name Zynlonta, is a monoclonal antibody conjugate medication used to treat large B-cell lymphoma and high-grade B-cell lymphoma. [ 1 ] [ 2 ] It is an antibody-drug conjugate (ADC) composed of a humanized antibody targeting the protein CD19 .
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