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Melatonin is one of the most popular natural sleep aids on the market. Dr. Dr. Singh notes that compared to many other options, it has the largest amount of research behind it.
The clear formula contains small liposomes that allow for effective absorption and bioavailability, so this is an excellent choice if you want to take melatonin just before turning in for the night.
“Melatonin is most effective for helping sleep, but also helps with nighttime acid reflux, along with antioxidant, immune, and neuroprotective benefits,” he says.
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
Melatonin is a safer alternative than clonazepam in the treatment of REM sleep behavior disorder – a condition associated with the synucleinopathies like Parkinson's disease and dementia with Lewy bodies. [32] [33] [34] However, clonazepam may be more effective. [35]
The one exception, where melatonin is effective, is the "circadian abnormality" DSPD. [49] Another systematic review found inconsistent evidence for the efficacy of melatonin in treating DSPD in adults, and noted that it was difficult to draw conclusions about its efficacy because many recent studies on the subject were uncontrolled. [50]