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In molecular biology, protein aggregation is a phenomenon in which intrinsically-disordered or mis-folded proteins aggregate (i.e., accumulate and clump together) either intra- or extracellularly. [1] [2] Protein aggregates have been implicated in a wide variety of diseases known as amyloidoses, including ALS, Alzheimer's, Parkinson's and prion ...
Accretion is defined as the gradual collection of something over time. [1] In meteorology or atmospheric science it is the process of accumulation of frozen water as precipitation over time as it descends through the atmosphere, in particular when an ice crystal or snowflake hits a supercooled liquid droplet, which then freeze together, increasing the size of the water particle.
The accumulation of platelets to the site of a wound to form a platelet plug or a thrombus; Flocculation, a process where a solute comes out of solution in the form of floccules or flakes; Overdispersion or statistical aggregation, where the variance of a distribution is higher than which we expect. Aggregation pheromone
In astrophysics, accretion is the accumulation of particles into a massive object by gravitationally attracting more matter, typically gaseous matter, into an accretion disk. [1] [2] Most astronomical objects, such as galaxies, stars, and planets, are formed by accretion processes.
Atomic force microscopy, which can visualize nanoscale molecular surfaces, can be used to determine the aggregation state of amyloid beta in vitro. [76] Vibrational microspectroscopy is a label-free method that measures the vibration of molecules in tissue samples. [77]
In general, amyloid polymerization (aggregation or non-covalent polymerization) is sequence-sensitive, that is mutations in the sequence can induce or prevent self-assembly. [ 61 ] [ 62 ] For example, humans produce amylin , an amyloidogenic peptide associated with type II diabetes, but in rats and mice prolines are substituted in critical ...
Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1] Amyloid beta is a short peptide that is an abnormal proteolytic byproduct of the transmembrane protein amyloid-beta precursor protein (APP), whose function is ...
Soil structure describes the arrangement of the solid parts of the soil and of the pore spaces located between them (Marshall & Holmes, 1979). [1] Aggregation is the result of the interaction of soil particles through rearrangement, flocculation and cementation.