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Histiocytes are derived from the bone marrow by multiplication from a stem cell. The derived cells migrate from the bone marrow to the blood as monocytes . They circulate through the body and enter various organs, where they undergo differentiation into histiocytes, which are part of the mononuclear phagocytic system (MPS).
In medicine, histiocytosis is an excessive number of histiocytes [1] (tissue macrophages), and the term is also often used to refer to a group of rare diseases which share this sign as a characteristic. Occasionally and confusingly, the term histiocytosis is sometimes used to refer to individual diseases.
Malignant histiocytosis is a rare hereditary disease found in the Bernese Mountain Dog and humans, characterized by histiocytic infiltration of the lungs and lymph nodes. The liver, spleen, and central nervous system can also be affected. Histiocytes are a component of the immune system that proliferate abnormally in this disease. In addition ...
Multinucleated giant cells due to an infection. H&E stain.. A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma.
[1] [2] Histiocytosis is an excessive number of histiocytes (an immune cell type which is part of the mononuclear phagocyte system). In the vast majority of crystal-storing histiocytosis cases (over 90%), immunoglobulins accumulate within the cytoplasm of histiocytes; [ 1 ] [ 2 ] [ 3 ] in rare cases clofazimine , cystine , silica , or Charcot ...
The adult human body is estimated to contain about 30 trillion (3×10 13) human cells, with the number varying between 20 and 100 trillion depending on factors such as sex, age, and weight. Additionally, there are approximately an equal number of bacterial cells.
These cells in combination with lymphocytes, eosinophils, and normal histiocytes form typical LCH lesions that can be found in almost any organ. [5] A similar set of diseases has been described in canine histiocytic diseases. [6] LCH is clinically divided into three groups: unifocal, multifocal unisystem, and multifocal multisystem. [7]
A histiocytoma is a tumour consisting of histiocytes. [1] Histiocytes are cells that are a part of the mononuclear phagocytic system, a part of the body's immune system that consists of phagocytic cells, which are responsible for engulfing solid particles by the cell membrane to form an internal phagosome by phagocytes and protists.