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An application of the study of somatic mosaicism in the brain could be the tracing of specific brain cells. Indeed, if the somatic L1 insertions occurs in a progenitor cell, the unique variant could be used to trace the progenitor cell's development, localization, and spreading through the brain. On the contrary, if the somatic L1 insertion ...
Mutations in neuronal stem cells (especially during neurogenesis) [18] and in post-mitotic neurons lead to genomic heterogeneity of neurons—referred to as "somatic brain mosaicism". [3] The accumulation of age-related mutations in neurons may be linked to neurodegenerative diseases, including Alzheimer's disease, but the association is ...
Due to a loss-of-function mutation in the HNF4α gene. 5%–10% cases. GCK-MODY 125851: glucokinase: Due to any of several mutations in the GCK gene. 30%–70% cases. Mild fasting hyperglycemia throughout life. Small rise on glucose loading. Patients do not tend to get diabetes complications and do not require treatment [15] outside of ...
Most cancers are due to somatic mutations. Somatic is also defined as relating to the wall of the body cavity, particularly as distinguished from the head, limbs, or viscera. It is also used in the term somatic nervous system, which is the portion of the vertebrate nervous system that regulates voluntary movements of the body.
A change in the genetic structure that is not inherited from a parent, and also not passed to offspring, is called a somatic mutation. [89] Somatic mutations are not inherited by an organism's offspring because they do not affect the germline. However, they are passed down to all the progeny of a mutated cell within the same organism during ...
Somatic hypermutation (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes).A major component of the process of affinity maturation, SHM diversifies B cell receptors used to recognize foreign elements and allows the immune system to adapt its response to new threats during the lifetime of an organism. [1]
A group of closely related viruses is called a lineage and the direct descendants of each variant are referred to as a sublineages — for example, BA.2.75 is a sublineage of BA.2.
Somatic recombination, as opposed to the genetic recombination that occurs in meiosis, is an alteration of the DNA of a somatic cell that is inherited by its daughter cells. The term is usually reserved for large-scale alterations of DNA such as chromosomal translocations and deletions and not applied to point mutations .