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RIPK1 protein is composed of 671 amino acids, and has a molecular weight of about 76 kDa. It contains a serine/threonine kinase domain (KD) in the 300 aa N-Terminus, a death domain (DD) in the 112 aa C-Terminus, and a central region between the KD and DD called intermediate domain (ID).
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
RIPK3 is believed to contribute to lung inflammation and injury during severe infections with the influenza A virus.The experimental RIPK3 inhibitor UH15-38 has shown potential in preclinical studies to reduce mortality and lung damage in mice infected with influenza, indicating that RIPK3 may serve as a therapeutic target for managing hyper-inflammatory conditions such as influenza-related ...
Google Translate is a multilingual neural machine translation service developed by Google to translate text, documents and websites from one language into another. It offers a website interface, a mobile app for Android and iOS, as well as an API that helps developers build browser extensions and software applications. [3]
Eukaryotic translation is the biological process by which messenger RNA is translated into proteins in eukaryotes. It consists of four phases: initiation, elongation, termination, and recapping. It consists of four phases: initiation, elongation, termination, and recapping.
9261 17164 Ensembl ENSG00000162889 ENSMUSG00000016528 UniProt P49137 P49138 RefSeq (mRNA) NM_004759 NM_032960 NM_008551 RefSeq (protein) NP_004750 NP_116584 NP_032577 Location (UCSC) Chr 1: 206.68 – 206.73 Mb Chr 1: 130.98 – 131.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene ...
[5] [6] It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway. [7] As the name suggests, its target substrate is the S6 ribosomal protein. [8] Phosphorylation of S6 induces protein synthesis at the ribosome.
5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low.