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Methenamine was only used as a urinary antiseptic in cases of acidic urine, whereas boric acid was used to treat UTIs with alkaline urine. [47] The drug name methenamine , a contraction of the chemical or scientific name hexamethylenetetramine , was formally introduced and designated by the United States Pharmacopeia (USP) by 1925 and replaced ...
Methenamine, whether used alone or in combination with sodium salicylate, is considered an alternative to antibiotics for the treatment and prevention of UTIs and related symptoms. [5] [1] Unlike antibiotics, methenamine does not contribute to the risk of bacterial resistance. [1] [2] [6]
TMP/SMX is commonly used due to its ability to achieve high concentrations in urinary tract tissues and urine. This antibiotic combination demonstrates notable efficacy in both the treatment and prophylaxis of recurrent urinary tract infections. [12] Common adverse effects include nausea, vomiting, rash,pruritus, and photosensitivity. [26]
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The compound is also used medically as a urinary antiseptic and antibacterial medication under the name methenamine or hexamine. [4] [10] [11] [12] It is used as an alternative to antibiotics to prevent urinary tract infections (UTIs) and is sold under the brand names Hiprex, Urex, and Urotropin, among others. [4] [10] [12]
Fosfomycin can be used as an effective treatment for both UTIs and complicated UTIs including acute pyelonephritis. [87] The standard regimen for complicated UTIs is an oral 3g dose administered once every 48 or 72 hours for a total of 3 doses or a 6 grams every 8 hours for 7 days to 14 days when fosfomycin is given in IV form.