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Eventually, heart failure can result, which carries a 50% mortality rate. [21] There is no effective treatment against established cardiomyopathy caused by the drug as of 2010. [ 21 ] The drug dexrazoxane , which is an iron chelator may be used to decrease the risk of doxorubicin's cardiotoxicity in certain cases.
As an example, the incidence of congestive heart failure is 4.7%, 26% and 48% respectively when patients received doxorubicin at 400 mg/m 2, 550 mg/m 2 and 700 mg/m 2. [4] Therefore, the lifetime cumulative doxorubicin exposure is limited to 400–450 mg/m 2 in order to reduce congestive heart failure incidence to less than 5%, although ...
Cardiotoxicity is the occurrence of heart dysfunction as electric or muscle damage, resulting in heart toxicity. [1] This can cause heart failure, arrhythmia, myocarditis, and cardiomyopathy in patients. [2] Some effects are reversible, while in others, permanent damage requiring further treatment may arise.
Obstructive sleep apnea (a condition of sleep wherein disordered breathing overlaps with obesity, hypertension, and/or diabetes) is regarded as an independent cause of heart failure. [42] Recent reports from clinical trials have also linked variation in blood pressure to heart failure [43] [44] and cardiac changes that may give rise to heart ...
However, heart failure can also result from conditions or lifestyles you might have some command over, such as high blood pressure, diabetes, coronary heart disease, untreated sleep apnea, obesity ...
Neutropenia, thrombocytopenia, lymphopenia, hypertension, left ventricular dysfunction, heart failure, blood clots, thyroid dysfunction, electrolyte anomalies, pancreatitis (uncommon), hepatic failure (uncommon), prolonged QT interval (rare), torsades de pointes (rare), GI perforation (rare), fistula formation (rare), seizures (rare ...
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