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Macrophages are found in essentially all tissues, [4] where they patrol for potential pathogens by amoeboid movement. They take various forms (with various names) throughout the body (e.g., histiocytes, Kupffer cells, alveolar macrophages, microglia, and others), but all are part of the mononuclear phagocyte system.
A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. [1] Lymphocytes include T cells (for cell-mediated and cytotoxic adaptive immunity), B cells (for humoral, antibody-driven adaptive immunity), [2] [3] and innate lymphoid cells (ILCs; "innate T cell-like" cells involved in mucosal immunity and homeostasis), of which natural killer cells are an ...
Lymph nodes contain lymphocytes, a type of white blood cell, and are primarily made up of B cells and T cells. [5] B cells are mainly found in the outer cortex where they are clustered together as follicular B cells in lymphoid follicles, and T cells and dendritic cells are mainly found in the paracortex. [19]
In immunology, the mononuclear phagocyte system or mononuclear phagocytic system (MPS) also known as the macrophage system is a part of the immune system that consists of the phagocytic cells [1] located in reticular connective tissue. The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen.
The cells of the lymph are mostly lymphocytes. Associated lymphoid organs are composed of lymphoid tissue, and are the sites either of lymphocyte production or of lymphocyte activation. These include the lymph nodes (where the highest lymphocyte concentration is found), the spleen, the thymus, and the tonsils.
These cells reside in every tissue of the body, and upon infected tissue, are recruited to the tissue. Once recruited, macrophages will differentiate into specific tissue macrophages. The receptors of macrophages consist of a broad specificity that allows them to discern between self and non-self in the non-specific recognition of foreign ...
Types of white blood cells are granulocytes (neutrophils, eosinophils, and basophils), and agranulocytes (monocytes, and lymphocytes (T cells and B cells)). [5] Myeloid cells include neutrophils, eosinophils, mast cells, basophils, and monocytes. [6] Monocytes are further subdivided into dendritic cells and macrophages.
The tingible body macrophages express: tyrosine kinase Mer, the milk fat globule epidermal growth factor 8 and Tim-4, all of which supports the engulfment of the apoptotic cells into the macrophages. Macrophages are also present in the T cell area of the white pulp but their role is less well understood.