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Zinc and vitamin D are also essential for bone health but have the added benefit for men over 50 by reducing the risk of erectile dysfunction, a condition commonly affecting men over age 40 ...
Vitamin D (the inactive version) is mainly from two forms: vitamin D 3 and vitamin D 2.Vitamin D 3, or cholecalciferol, is formed in the skin after exposure to sunlight or ultra violet radiation or from D 3 supplements or fortified food sources.
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For example, CYP11A1, an enzyme chiefly known for its role in steroidogenesis, has been found to hydroxylate vitamin D3 at several positions, including C-20, C-22, and C-23, without cleaving the side chain. The resulting metabolites, such as 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3, act as inverse agonists for RORα and RORγ2.
Ergocalciferol is available as a generic medication and over the counter. [6] In 2022, it was the 38th most commonly prescribed medication in the United States, with more than 15 million prescriptions. [10] [11] Certain foods such as breakfast cereal and margarine have ergocalciferol added to them in some countries.
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Ergosterol (ergosta-5,7,22-trien-3β-ol) is a mycosterol found in cell membranes of fungi and protozoa, serving many of the same functions that cholesterol serves in animal cells.
LD 50 of 4.4 mg/kg has been reported in rabbits, with lethality to almost all rabbits ingesting doses greater than 15 mg/kg. [54] Toxicity has been reported across a wide range of cholecalciferol dosages, with LD 50 as high as 88 mg/kg or LD Lo as low as 2 mg/kg reported for dogs. [55]