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Parietal cells (also known as oxyntic cells) are epithelial cells in the stomach that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and body regions of the stomach. [ 1 ]
Fundic glands found in the fundus and also in the body have another two cell types–gastric chief cells and parietal cells (oxyntic cells). Foveolar cells (surface mucous cells) are mucus-producing cells which cover the inside of the stomach, protecting it from the corrosive nature of gastric acid.
The parietal cells in the fundus of the stomach, produce a glycoprotein called intrinsic factor which is essential for the absorption of vitamin B12. Vitamin B12 (cobalamin), is carried to, and through the stomach, bound to a glycoprotein secreted by the salivary glands – transcobalamin I also called haptocorrin, which protects the acid ...
Fundic glands are simple, branched tubular glands that extend from the bottom of the gastric pits to the muscularis mucosae; the more distinctive cells are parietal cells. H&E stain. Histology of normal antral mucosa. Antral mucosa is formed by branched coiled tubular glands lined by secretory cells similar in appearance to the surface mucous ...
In the pyloric region the glands are known as pyloric glands, and in the rest of the stomach they are called gastric glands. [1] Several types of endocrine cells are found in the gastric glands. The pyloric glands contain gastrin-producing cells ; this hormone stimulates acid production from the parietal cells.
The duct is lined by columnar cells, continuous with the epithelium lining the surface of the mucous membrane of the stomach, the tubes by shorter and more cubical cell which are finely granular. The glands contain mucous cells and G cells that secrete gastrin. [8] The pylorus also contains scattered parietal cells and neuroendocrine cells.
Mucus is released in the stomach and intestine, and serves to lubricate and protect the inner mucosa of the tract. It is composed of a specific family of glycoproteins termed mucins and is generally very viscous. Mucus is made by two types of specialized cells termed mucous cells in the stomach and goblet cells in the intestines. Signals for ...
Gastric pits are indentations in the stomach which denote entrances to 3-5 tubular gastric glands. [ 1 ] [ 2 ] They are deeper in the pylorus than they are in the other parts of the stomach. The human stomach has several million of these pits which dot the surface of the lining epithelium .