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Affinity (taxonomy) – mainly in life sciences or natural history – refers to resemblance suggesting a common descent, phylogenetic relationship, or type. [1] The term does, however, have broader application, such as in geology (for example, in descriptive and theoretical works [2] [3]), and similarly in astronomy (for example, see "Centaur object" in the context of 2060 Chiron's close ...
In general, high-affinity ligand binding results from greater attractive forces between the ligand and its receptor while low-affinity ligand binding involves less attractive force. In general, high-affinity binding results in a higher occupancy of the receptor by its ligand than is the case for low-affinity binding; the residence time ...
Avidity (functional affinity) is the accumulated strength of multiple affinities. [2] For example, IgM is said to have low affinity but high avidity because it has 10 weak binding sites for antigen as opposed to the 2 stronger binding sites of IgG, IgE and IgD with higher single binding affinities. [citation needed]
A good fit corresponds with high affinity and low K d. The final biological response (e.g. second messenger cascade, muscle-contraction), is only achieved after a significant number of receptors are activated. Affinity is a measure of the tendency of a ligand to bind to its receptor. Efficacy is the measure of the bound ligand to activate its ...
Weak affinity chromatography [29] (WAC) is an affinity chromatography technique for affinity screening in drug development. [ 30 ] [ 31 ] WAC is an affinity-based liquid chromatographic technique that separates chemical compounds based on their different weak affinities to an immobilized target.
In chemistry, biochemistry, and pharmacology, a dissociation constant (K D) is a specific type of equilibrium constant that measures the propensity of a larger object to separate (dissociate) reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into its component ions.
In immunology, affinity maturation is the process by which T FH cell-activated B cells produce antibodies with increased affinity for antigen during the course of an immune response. With repeated exposures to the same antigen, a host will produce antibodies of successively greater affinities .
In open nomenclature it indicates that available material or evidence suggests that the proposed species is related to, has an affinity to, but is not identical to, the species with the binomial name it comes after. [1] The Latin word affinis can be translated as "closely related to", or "akin to". [2]