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This illustration demonstrates the normal kidney physiology, including the Proximal Convoluted Tubule (PCT), Loop of Henle, and Distal Convoluted Tubule (DCT). It also includes illustrations showing where some types of diuretics act, and what they do. Renal physiology (Latin renes, "kidneys") is the study of the physiology of the kidney.
The glomerulus (pl.: glomeruli) is a network of small blood vessels (capillaries) known as a tuft, located at the beginning of a nephron in the kidney. Each of the two kidneys contains about one million nephrons. The tuft is structurally supported by the mesangium (the space between the blood vessels), composed of intraglomerular mesangial cells.
Diagram outlining movement of ions in nephron, with the collecting ducts on the right. The collecting duct system is the final component of the kidney to influence the body's electrolyte and fluid balance. In humans, the system accounts for 4–5% of the kidney's reabsorption of sodium and 5% of the kidney's reabsorption of water. At times of ...
One of the measures of kidney function is the glomerular filtration rate (GFR). Other tests that can assess the function of the kidneys include assessment of electrolyte levels such as potassium and phosphate, assessment of acid-base status by the measurement of bicarbonate levels from a vein, and assessment of the full blood count for anaemia.
Diagram of the circulation related to a single glomerulus, associated tubule, and collecting system The renal corpuscle in the cortex (outer layer) of the kidney. At the top, the renal corpuscle containing the glomerulus. The filtered blood exits into the renal tubule as filtrate, at right. At left, blood flows from the afferent arteriole (red ...
Diagram showing Bowman's capsule as part of the renal corpuscle. The process of filtration of the blood in the Bowman's capsule is ultrafiltration, and the normal rate of filtration is 125 ml/min, equivalent to 80 times the daily blood volume. [citation needed] It is a major site for blood filtration (including glomerulus)
The glomeruli are the filters in the kidneys. When working normally they will move the waste, excess electrolytes, and unnecessary fluid from the bloodstream to the urine. [8] When a person develops DPGN, over 50% of the glomeruli (diffuse) become inflamed. There is also an increase in mesangial, epithelial, and endothelial (proliferative) cells.
The kidneys in mammals are usually bean-shaped [4] or externally lobulated. [5] They are located behind the peritoneum (retroperitoneally) [6] on the back wall of the body. [7] The typical mammalian kidney consists of a renal capsule, a peripheral cortex, an internal medulla, one or more renal calyces, and a renal pelvis. [7]