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The name "satellite DNA" refers to the phenomenon that repetitions of a short DNA sequence tend to produce a different frequency of the bases adenine, cytosine, guanine, and thymine, and thus have a different density from bulk DNA such that they form a second or "satellite" band(s) when genomic DNA is separated along a cesium chloride density ...
The genome is a single circular single strand DNA molecule. [1] The first alphasatellites were described in 1999 and were associated with cotton leaf curl disease and Ageratum yellow vein disease. [ 2 ] [ 3 ] As begomoviruses are being characterised at the molecular level an increasing number of alphasatellites are being described.
In most eukaryotes, the centromere's DNA sequence consists of large arrays of repetitive DNA (e.g. satellite DNA) where the sequence within individual repeat elements is similar but not identical. In humans, the primary centromeric repeat unit is called α-satellite (or alphoid), although a number of other sequence types are found in this ...
HACs were first constructed de novo in 1997 by adding alpha-satellite DNA to telomeric and genomic DNA in human HT1080 cells. This resulted in an entirely new microchromosome that contained DNA of interest, as well as elements allowing it to be structurally and mitotically stable, such as telomeric and centromeric sequences. [6]
The name derives from the small chromosomal segment behind the secondary constriction, called a satellite, named by Sergei Navashin, in 1912. [5] Later, Heitz (1931) qualified the secondary constriction as the SAT state ( Sine Acido Thymonucleinico , which means "without thymonucleic acid"), because it didn't stain with the Feulgen reaction .
There exist three copies of this human region on the chimpanzee Y chromosome with two surrounding the Y chromosome centromere and the third located at Yp11.2. Both the human region and the homologous chimpanzee region are encompassed by typical alpha-satellite DNA found near the chromosome centromeres.
The 200-foot-tall balloon was loaded with a satellite communication module, sensors and other technology from at least five American firms, two sources with direct knowledge of a classified US ...
The position of CENPA within satellite DNA are heritable at the protein level through a purely epigenetic mechanism. [17] This means that the position of CENPA protein binding to the genome is copied upon cell division to the two daughter cells independent of the underlying DNA sequence.