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Use in pregnancy may harm the baby and use when breastfeeding is not recommended. [10] It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II. [5] Irbesartan was patented in 1990, and approved for medical use in 1997. [11] It is available as a generic medication. [9]
Use in pregnancy may harm the baby and use when breastfeeding is not recommended. [9] It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II. [8] Valsartan was patented in 1990, and came into medical use in 1996. [10] It is available as a generic medication. [11]
The angiotensin II receptor blockers have differing potencies in relation to blood pressure control, with statistically differing effects at the maximal doses. [11] When used in clinical practice, the particular agent used may vary based on the degree of response required. Some of these drugs have a uricosuric effect. [12] [13]
Antihypertensive agents are classified according to their mechanism of actions. The most common classes prescribed are diuretics, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs) and beta-blockers. Antihyperlipidemic agents most often prescribed are statins, ezetimibe and ...
Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). [4] It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys.
Candesartan is an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure. Candesartan has a very low maintenance dose . Like olmesartan , the metabolism of the drug is unusual as it is a cascading prodrug .
The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure.
The angiotensin receptor is activated by the vasoconstricting peptide angiotensin II. The activated receptor in turn couples to G q/11 and G i/o and thus activates phospholipase C and increases the cytosolic Ca 2+ concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.