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Trazodone, sold under many brand names, [1] is an antidepressant medication [20] used to treat major depressive disorder, anxiety disorders, and insomnia. [20] It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class. [21] [22] The medication is taken orally. [20]
Some studies found that the abrupt substitution of substitutive pharmacotherapy was actually less effective than gradual dose reduction alone, and only three studies found benefits of adding melatonin, [74] paroxetine, [75] trazodone, [76] or valproate [76] in conjunction with a gradual dose reduction. [71]
Melatonin supplements and trazodone are commonly used to regulate sleep disturbances. In combination with exogenous melatonin, blockade of endogenous melatonin production during the day by the adrenergic antagonist acebutolol can increase concentration, improve sleep and sleep timing and aid in improvement of behaviour. [ 13 ]
This is how melatonin helps regulate our circadian rhythm, which is our biological 24-hour clock,” Dr. Dasgupta says, adding that we sleep best when melatonin is secreted appropriately.
The popular sleep aid can have side effects.
While melatonin is generally considered safe, it can have side effects or interfere with medication. Here's how and when to use this sleep-promoting supplement, according to experts.View Entire ...