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The human stomach can be divided into four sections, beginning at the cardia followed by the fundus, the body and the pylorus. [ 7 ] [ 8 ] The gastric cardia is where the contents of the esophagus empty from the gastroesophageal sphincter into the cardiac orifice, the opening into the gastric cardia.
Gastrointestinal physiology is the branch of human physiology that addresses the physical function of the gastrointestinal (GI) tract.The function of the GI tract is to process ingested food by mechanical and chemical means, extract nutrients and excrete waste products.
The human digestive system consists of the gastrointestinal tract plus the accessory organs of digestion (the tongue, salivary glands, pancreas, liver, and gallbladder). Digestion involves the breakdown of food into smaller and smaller components, until they can be absorbed and assimilated into the body.
The human gastrointestinal tract consists of the esophagus, stomach, and intestines, and is divided into the upper and lower gastrointestinal tracts. [3] The GI tract includes all structures between the mouth and the anus , [ 4 ] forming a continuous passageway that includes the main organs of digestion, namely, the stomach , small intestine ...
The muscle of the inner layer is arranged in circular rings around the tract, whereas the muscle of the outer layer is arranged longitudinally. The stomach has an extra layer, an inner oblique muscular layer. [1] Between the two muscle layers is the myenteric plexus (Auerbach's plexus). This controls peristalsis.
In 1823, William Prout discovered that stomach juices contain hydrochloric acid. [12] In 1833, William Beaumont published Experiments and Observations on the Gastric Juice and the Physiology of Digestion following years of experimenting on test subject Alexis St. Martin. In 1868, Adolf Kussmaul, a well-known German physician, developed the ...
Acidity in the stomach is not buffered by food at this point and thus acts to inhibit parietal (secretes acid) and G cell (secretes gastrin) activity via D cell secretion of somatostatin. The gastric phase takes 3 to 4 hours. It is stimulated by distension of the stomach, presence of food in stomach and decrease in pH. Distention activates long ...
Distension of the stomach increases motility of the stomach. [2] Distension of the duodenum inhibits stomach motility in order to prevent the over filling of the duodenum. [2] Presence of fat, low pH, and hypertonic solutions cause a decrease in motility of the stomach. [2] Sympathetic nervous system innervation inhibits gastric motility. [2]