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  2. Selective serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Selective_serotonin...

    This side effect has been particularly associated with serotonergic antidepressants like SSRIs and SNRIs, but may be less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. [83] [85] [86] Higher doses of antidepressants seem to be more likely to produce emotional blunting than lower doses. [83]

  3. Noradrenergic and specific serotonergic antidepressant

    en.wikipedia.org/wiki/Noradrenergic_and_specific...

    Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1] They act by antagonizing the α 2 -adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C , [ 1 ] but also 5-HT 3 , [ 1 ] 5-HT 6 , and/or 5-HT 7 in some cases.

  4. Serotonin–norepinephrine reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Serotonin–norepinephrine...

    Several studies have shown that antidepressant drugs which have combined serotonergic and noradrenergic activity are generally more effective than SSRIs, which act upon serotonin reuptake by itself. Serotonergic-noradrenergic antidepressant drugs may have a modest efficacy advantage compared to SSRIs in treating major depressive disorder (MDD ...

  5. Do Antidepressants Boost Serotonin? A New Study Says No - AOL

    www.aol.com/lifestyle/antidepressants-boost...

    A study finds that antidepressants don’t boost the feel-good brain chemical serotonin, as previously thought. Here’s what you need to know.

  6. Serotonin–norepinephrine–dopamine reuptake inhibitor

    en.wikipedia.org/wiki/Serotonin–norepinephrine...

    However, most antidepressant treatments do not directly enhance DA neurotransmission, which may contribute to residual symptoms, including impaired motivation, concentration, and pleasure. [ 21 ] Preclinical and clinical research indicates that drugs inhibiting the reuptake of all three of these neurotransmitters can produce a more rapid onset ...

  7. Serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Serotonin_reuptake_inhibitor

    This in turn leads to increased extracellular concentrations of serotonin and, therefore, an increase in serotonergic neurotransmission. It is a type of monoamine reuptake inhibitor (MRI); other types of MRIs include dopamine reuptake inhibitors and norepinephrine reuptake inhibitors.

  8. No ‘clear evidence’ depression is caused by low serotonin levels

    www.aol.com/no-clear-evidence-depression-caused...

    NHS figures show that the number of people in England taking antidepressants continues to rise, with 8.3m patients receiving them in 2021/22. No ‘clear evidence’ depression is caused by low ...

  9. MDMA/citalopram - Wikipedia

    en.wikipedia.org/wiki/MDMA/citalopram

    MDMA/citalopram is a combination of the entactogen and monoamine releasing agent 3,4-methylenedioxymethamphetamine (MDMA; also known as midomafetamine or "ecstasy") and the selective serotonin reuptake inhibitor (SSRI) citalopram which is under development for the treatment of post-traumatic stress disorder (PTSD).