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It can occur anywhere within the spinal cord and cerebrum and can have multiple sites of origins, with a high probability of metastasis through cerebrospinal fluid (CSF). [1] [2] PNET has five subtypes of tumors: neuroblastoma, ganglioneuroblastoma, medulloepithelioma, ependymoblastoma, and not otherwise specified PNET. [1]
Modified tight junctions between epithelial cells control fluid release. This release allows free exchange between CSF and nervous tissue of brain and spinal cord. This is why sampling of CSF, such as through a spinal tap, provides information about the whole CNS.
The lateral corticospinal tract is a descending motor pathway that begins in the cerebral cortex, decussates in the pyramids of the lower medulla [1] (also known as the medulla oblongata or the cervicomedullary junction, which is the most posterior division of the brain [2]) and proceeds down the contralateral side of the spinal cord.
Most symptoms from spinal tumors occur due to compression of the spinal cord as it plays a primary role in motor and sensory function. [13] The spinal cord is surrounded by three layers known as the spinal meninges. [13] These are the dura mater, arachnoid mater, and pia mater. Spinal cord tumors are classified based on their location within ...
The blood–cerebrospinal fluid barrier (BCSFB) is a fluid–brain barrier that is composed of a pair of membranes that separate blood from CSF at the capillary level and CSF from brain tissue. [14] The blood–CSF boundary at the choroid plexus is a membrane composed of epithelial cells and tight junctions that link them. [14]
Unveiled in July 2008, the Allen Mouse Spinal Cord Atlas was the first genome-wide map of the mouse spinal cord ever constructed. The spinal cord atlas is a map of genome wide gene expression in the spinal cord of adult and juvenile C57 black mice. The initial unveiling included data for 2,000 genes and an anatomical reference section. A plan ...
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