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HLA-DQ2 (DQ2) is a serotype group within HLA-DQ (DQ) serotyping system. The serotype is determined by the antibody recognition of β 2 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB1 *02 allele group. This group currently contains two common alleles, DQB1 *0201 and DQB1 *0202.
DQ2.5: HLA associations: DQ8: DQ2.2/DQ7.5: Associated T-Cell restrictions: DQ/gliadin, DQ/deamidated-gliadin Triggering agent(s) Triticeae glutens (Prolamins and Glutelins) Isoform specific : autoantibody characteristics : Autoantigen Isoform: Tissue transglutaminase: Autoantigen Gene: TGM2: Affected Organ(s) Intestine (small) Affected Tissue(s ...
HLA class I restrictions to gliadin are not well characterized. HLA-A2 presentation has been investigated. The HLA-A antigens can mediate apoptosis in autoimmune disease and HLA A*0201 in with the HLA-DQ8 haplotypes has been documented. [13] The class I sites were found on the carboxyl end of gliadin at positions 123–131, 144–152, and 172 ...
An example of a serotype is DQ2. Recognize HLA-DQB1*02 gene products which include gene products of the following alleles: HLA-DQB1*02:01; HLA-DQB1*02:02; HLA-DQB1*02:03; Sometimes DQ2 antibodies recognize other gene products, such as DQB1*03:03, resulting in serotyping errors. Because of this mistyping serotyping is not as reliable as gene ...
There are four commonly encountered DQA1 alleles: DQA1*0101, *0102, *0103, *0104. These alleles are always found in haplotypes with HLA-DQB1*05 and HLA-DQB1*06 . DQ1 is a serotype, rare among serotypes for human class II antigens, in that the antibodies to DQ1 react to the alpha chain of HLA DQ, these DQA1 allele gene products.
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HLA region of Chromosome 6. The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]
Sensitivity can be improved by knowing the haplotype. In Europe, HLA-A1 is strongly linked to a 'chunk of chromosome' called a 'haplotype'. This haplotype, Super-B8, is A1-Cw7-B8-DR3-DQ2, about 2 million DNA codons (the nucleotide building blocks) long. This chunk has avoided recombination for thousands of years.