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An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
"Pain ladder", or analgesic ladder, was created by the World Health Organization (WHO) as a guideline for the use of drugs in the management of pain. Originally published in 1986 for the management of cancer pain, it is now widely used by medical professionals for the management of all types of pain.
Because of fentanyl's high lipid solubility, its effects are more localized than morphine, and some clinicians prefer to use morphine to get a wider spread of analgesia. [37] It is widely used in obstetrical anesthesia because of its short time to action peak (about 5 minutes), the rapid termination of its effect after a single dose, and the ...
Fentanyl is a powerful synthetic opioid similar to morphine but 50 to 100 times more potent, according to the DEA. It is approved by the Food and Drug Administration for use as an analgesic (pain ...
Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time."
The weakest compounds such as benzylfentanyl are around the same potency as codeine (i.e. approximately 1/10th the potency of morphine), while the strongest compounds such as carfentanil and ohmefentanil can be over 10,000x more potent than morphine, meaning there is a 100,000-fold variation in potency between the strongest and weakest fentanyl ...
ortho-Fluoroisobutyryl fentanyl [19] 9848 ortho-Methyl acetylfentanyl [12] 9820 ortho-Methyl methoxyacetyl fentanyl [12] 9826 para-Chloroisobutyryl fentanyl [24] 9823 para-Fluorobutyryl fentanyl [12] 9812 Para-fluorofentanyl [3] 9854 para-Fluoro furanyl fentanyl [19] 9837 para-Methoxybutyryl fentanyl [16] 9817 para-Methylfentanyl [12] 9663 ...
β-Hydroxyfentanyl is an opioid analgesic that is an analogue of fentanyl.. β-Hydroxyfentanyl was sold briefly on the black market in the early 1980s, before the introduction of the Federal Analog Act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared.