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Skeletal formula of tetracycline with atoms and four rings numbered and labeled.. Tetracyclines are a group of broad-spectrum antibiotic compounds that have a common basic structure and are either isolated directly from several species of Streptomyces bacteria or produced semi-synthetically from those isolated compounds. [1]
Tetracycline hydrochloride is available as yellow crystalline powder. Since tetracycline is absorbed into bone, it is used as a marker of bone growth for biopsies in humans. Tetracycline labeling is used to determine the amount of bone growth within a certain period of time, usually a period around 21 days.
The overall structure of TetR can be broken down into two DNA-binding domains (one per monomer) and a regulatory core, which is responsible for tetracycline recognition and dimerization. TetR dimerizes by making hydrophobic contacts within the regulatory core. There is a binding cavity for tetracycline in the outer helices of the regulatory domain.
The molecular formula C 22 H 24 N 2 O 8 (molar mass: 444.43 g/mol, exact mass: ... Tetracycline; Doxycycline This page was last edited on 15 February 2021, at 05: ...
Pages in category "Tetracycline antibiotics" The following 20 pages are in this category, out of 20 total. This list may not reflect recent changes. ...
Ammonia, NH 3, is a molecule whose three N−H bonds have only a slight polarity (toward the more electronegative nitrogen atom). The molecule has two lone electrons in an orbital that points towards the fourth apex of an approximately regular tetrahedron, as predicted by the VSEPR theory. This orbital is not participating in covalent bonding ...
Tetracene is a molecular organic semiconductor, used in organic field-effect transistors (OFETs) and organic light-emitting diodes (OLEDs). Tetracene can be used as a gain medium in dye lasers as a sensitiser in chemoluminescence. Napthacene is the main component of the tetracycline class of antibiotics.
Tetracycline-controlled gene expression is based upon the mechanism of resistance to tetracycline antibiotic treatment found in gram-negative bacteria. In nature, the P tet promoter expresses TetR (the repressor) and TetA, the protein that pumps tetracycline antibiotic out of the cell. [2]