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Of nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell skin cancers. [14] Basal-cell and squamous-cell skin cancers rarely result in death. [6] In the United States, they were the cause of less than 0.1% of all cancer deaths. [1] Globally in 2012, melanoma occurred in 232,000 people and resulted in 55,000 deaths. [6]
Cutaneous squamous-cell carcinoma is the second-most common cancer of the skin (after basal-cell carcinoma, but more common than melanoma). It usually occurs in areas exposed to the sun. Sunlight exposure and immunosuppression are risk factors for SCC of the skin, with chronic sun exposure being the strongest environmental risk factor. [26]
Squamous-cell carcinoma of the skin is generally distinguishable by for example relatively more cytoplasm, horn cyst formation and absence of palisading and cleft formations. Yet, a high prevalence means a relatively high incidence of borderline cases, such as basal-cell carcinoma with squamous cell metaplasia (H&E stain at left in image).
A personal history of basal cell or squamous cell skin cancer, or a family history of melanoma. Many moles or atypical moles that have irregular borders, different colors or may be asymmetrical.
Skin cancer is the most common form of cancer nationwide each year, according to the Centers for Disease Control and Prevention. What causes skin cancer? What to know about basal cell carcinoma ...
According to the American Academy of Dermatology, the two most common types of skin cancers are basal cell carcinoma, squamous cell carcinoma. Skin cancer is usually caused by exposure to UV rays ...